Cyclophilin F Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90362-50, BS90362-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P30405(Human) Q99KR7(Mouse) P29117(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IP,

All Applications: WB:1:500-1:2,000
IHC:1:50-1:200

Background: Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of cyclosporin A (CsA) and is encoded by a single unique gene conserved between yeast to humans. Cyclophilin B (CyPB) is secreted in biological fluids such as blood or milk, and binds to a specific receptor present on human peripheral blood lymphocytes and expressed in Jurkat cells, a line of human lymphoblasts. Cyclophilin D (CyP40) is a widely expressed cytoplasmic protein that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Cyclophilin F (CyP3), is also known as PPIF, Cyp-D or Rotamase F, is a 207 amino acid mitochondrial matrix protein involved in the induction of necrotic and apoptotic cell death through the activation of the mitochondrial permeability transition (mPT) pore.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Cyclophilin F polyclonal antibody detects endogenous levels of Cyclophilin F protein.

Bioworld Molecular Weight: 20 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Cyclophilin F on human heart (1) and human brain (2) tissue lysate using anti-Cyclophilin F antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Cyclophilin F antibody. Counter stained with hematoxylin.

Alternative Name: PPIase F, CyP-D, CypD, CyP-M, PPIF, CYP3,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified