Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523).

Product information

CAS Number: 86259-89-4

Molecular Weight: 432.53

Formula: C20H32O8S

Chemical Name: 2-(2-{2-[2-(oxan-2-yloxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzene-1-sulfonate

Smiles: CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOC1CCCCO1

InChiKey: AWIUPDGEVFBSGD-UHFFFAOYSA-N

InChi: InChI=1S/C20H32O8S/c1-18-5-7-19(8-6-18)29(21,22)28-17-15-25-13-11-23-10-12-24-14-16-27-20-4-2-3-9-26-20/h5-8,20H,2-4,9-17H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

1. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.

Products are for research use only. Not for human use.