Prepare yourself for this terrifying, twisted, and chilling film. From director James Gunn comes the deliciously demented story of an unnamed evil wreaking havoc on a small town. Intent on devouring all life on Earth, this dark force is infecting anyone in its path. Now, it's up to the local sheriff, Bill Pardy (Nathan Fillion), and his team to stop the spread of rampant devastation—and shocking mutilation—before it's too late.

Special Features:
- 4K Scan from the 35mm Interpositive Approved by Writer/Director James Gunn and Director of Photography Gregory Middleton
- Presented In Dolby Vision and Dolby Atmos
- Audio Commentary with Writer/Director James Gunn and Actors Nathan Fillion and Michael Rooker
- Audio Commentary with Writer/Director James Gunn and Actor Nathan Fillion
- We've Got Worms: Interview with Director of Photography Gregory Middleton
- Feed the Fear: Interview with Editor John Axelrad
- Just a Bee Sting: Interview with Special Make-up Effects Designer Todd Masters
- What's Gotten into You: Interview with Composer Tyler Bates
- The Genesis of Slither: Interview with Writer/Director James Gunn
- The Other MacReady: Interview with Actor Gregg Henry
- Deleted and Extended Scenes with Optional Commentary with James Gunn
- Visual Effects Progressions
- Slithery Set Tour with Actor Nathan Fillion
- The Sick Minds and Slimy Days of Slither Featurette
- Brewing the Blood Featurette
- Bringing Slither's Creatures to Life Featurette
- Lloyd Kaufman's Video Diary
- Gag Reel
- Who Is Bill Pardy? Featurette
- Theatrical Trailer